Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations by Delaney G. Fisher et al (2025)

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Focused ultrasound-microbubble (FUS-MS) shows promise in animal studies; anticipating clinical trial studies to prove efficacy and safety with respect to a treatment alternative for CCM.

Current and Future Treatment Options for Cerebral Cavernous Malformation by Leslie Morrison et al (2024)

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Discusses existing and potential future treatment options, focusing on both surgical and emerging pharmacological approaches.

Familial Cerebral Cavernous Malformations by Kelly D. Flemming et al (2023)

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Discusses CCMs including genetics, symptoms, diagnosis, and management.

Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level by Kelly D. Flemming et al (2020)

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Low 25-hydroxy-vitamin D levels are more common in patients with CM presenting with hemorrhage.​

Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations: a phase 1/2a, randomized placebo-controlled trial by Issam A. Awad et al (2025)

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Assesses the safety and efficacy of atorvastatin on rebleeding in patients with CCMs after a symptomatic hemorrhage. 

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation by Ying Li et al (2023)

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How inflammation may contribute to CCM, exploring the molecular and cellular mechanisms involved.

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations by Daniel A Snellings et al (2022)

 

Discusses somatic mutations which cause individual lesions, and interactions between mutations.

Peripheral Plasma Vitamin D and non-HDL Cholesterol Reflect the Severity of Cerebral Cavernous Malformation Disease by Romuald Girard et al (2016)

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Having lower vitamin D and non-HDL cholesterol levels is linked to increased severity in CCM.​

Mild Hypoxia Accelerates Cerebral Cavernous Malformation Disease Through CS3R1-CX3CL1 Signaling by Eduardo Firas-Anaya et al (2024)

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Mild hypoxia could impact CCM, promoting lesion growth based on mouse models.

Female Hormone Therapy and Risk of Intracranial Hemorrhage from Cerebral Cavernous Malformations: A Multicenter Observational Cohort Study by Susanna Zuurbier et al (2023)

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Explores the link between female hormone therapy and increased risk of brain hemorrhage in women with CCM.

Cerebral Cavernous Malformation: What a Practicing Clinician Should Know by Kelly D. Flemming and Giuseppe Lanzino (2020)

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Provides an overview of CCMs including epidemiology, clinical presentation, diagnosis via MRI, management strategies and prognosis.