Cavernous Malformation Research
Our research page features detailed studies of cavernous malformation (CM) conducted in various formats. Research is the critical foundation towards a cure for CM. The discovery of new information and novel understanding of the science behind CM also generates an improved quality of life for patients. As scientists strive to answer the important questions through systematic investigation, new pathways of discovery are unleashed.
Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations: a phase 1/2a, randomized placebo-controlled trial by Issam A. Awad et al (2025)
Assesses the safety and efficacy of atorvastatin on rebleeding in patients with CCMs after a symptomatic hemorrhage.
Mild hypoxia could impact CCM, promoting lesion growth based on mouse models.
Familial Cerebral Cavernous Malformations by Kelly D. Flemming et al (2023)
Discusses CCMs including genetics, symptoms, diagnosis, and management.
Discusses somatic mutations which cause individual lesions, and interactions between mutations.
Provides an overview of CCMs including epidemiology, clinical presentation, diagnosis via MRI, management strategies and prognosis.
Having lower vitamin D and non-HDL cholesterol levels is linked to increased severity in CCM.
Discusses existing and potential future treatment options, focusing on both surgical and emerging pharmacological approaches.
Explores the link between female hormone therapy and increased risk of brain hemorrhage in women with CCM.
Low 25-hydroxy-vitamin D levels are more common in patients with CM presenting with hemorrhage.
How inflammation may contribute to CCM, exploring the molecular and cellular mechanisms involved.