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Doctor analyzing brain scans

Cavernous Malformation Research

Our research page features detailed studies of cavernous malformation (CM) conducted in various formats. Research is the critical foundation towards a cure for CM. The discovery of new information and novel understanding of the science behind CM also generates an improved quality of life for patients. As scientists strive to answer the important questions through systematic investigation, new pathways of discovery are unleashed.

Focused ultrasound-microbubble treatment arrests the growth and formation of cerebral cavernous malformations by Delaney G. Fisher et al (2025)

Focused ultrasound-microbubble (FUS-MS) shows promise in animal studies; anticipating clinical trial studies to prove efficacy and safety with respect to a treatment alternative for CCM.

Current and Future Treatment Options for Cerebral Cavernous Malformation by Leslie Morrison et al (2024)

Discusses existing and potential future treatment options, focusing on both surgical and emerging pharmacological approaches.

Familial Cerebral Cavernous Malformations by Kelly D. Flemming et al (2023)

Discusses CCMs including genetics, symptoms, diagnosis, and management.

Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level by Kelly D. Flemming et al (2020)

Low 25-hydroxy-vitamin D levels are more common in patients with CM presenting with hemorrhage.

Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations: a phase 1/2a, randomized placebo-controlled trial by Issam A. Awad et al (2025)

Assesses the safety and efficacy of atorvastatin on rebleeding in patients with CCMs after a symptomatic hemorrhage. 

Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation by Ying Li et al (2023)

How inflammation may contribute to CCM, exploring the molecular and cellular mechanisms involved.

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations by Daniel A Snellings et al (2022)

 

Discusses somatic mutations which cause individual lesions, and interactions between mutations.

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